Differentiation and proliferation of pulmonary neuroendocrine cells
Read Online

Differentiation and proliferation of pulmonary neuroendocrine cells

  • 591 Want to read
  • ·
  • 11 Currently reading

Published by Urban & Fischer in Jena, Germany .
Written in English


  • Paraneurons -- Growth.,
  • Cell differentiation.,
  • Cell proliferation.,
  • Lungs -- Cytology.,
  • Lungs -- Cancer.

Book details:

Edition Notes

Includes bibliographical references and index.

StatementTakaaki Ito.
SeriesProgress in histochemistry and cytochemistry -- v. 34, no. 4.
LC ClassificationsQP356.4 .I86x 1999
The Physical Object
Paginationp. 254-322 :
Number of Pages322
ID Numbers
Open LibraryOL15569588M

Download Differentiation and proliferation of pulmonary neuroendocrine cells


Neuroendocrine Cells. The neuroendocrine cells are the least common cell type of the prostatic epithelium and are usually not identified in routine hematoxylin-eosin (H&E)–stained sections except for rare cells with large eosinophilic granules Although their function is unknown, neuroendocrine cells probably have an endocrine-paracrine regulatory role in growth and development, similar. Abstract. We review the significance of a network of proneural basic helix-loop-helix (bHLH) factors. Immunohistochemically, pulmonary neuroendocrine cells (PNECs) are positive for Mash1, one of the activator bHLHs, and non-PNECs such as Clara cells are positive for Hes1, one of the repressor by: Many dendritic neuroendocrine cell processes were seen between non-neuroendocrine epithelial cells adjacent to the basement membrane. The widely held belief that neuroendocrine cells are of little importance in the adult lung is contradicted by the relative high density of Cited by: Neuroendocrine differentiation is a term primarily used in relation to prostate cancers that display a significant neuroendocrine cell population on histopathological examination. These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype.

Pulmonary neuroendocrine cells and neuroepithelial bodies seem to be most important in the fetal and neonatal lung as regulators of airway development and hypoxia-sensitive chemoreceptors. There is a link between these cells and specific types of lung cancer and their involvement in lung and paediatric pathology may be by: Pulmonary Neuroendocrine Cells Pulmonary neuroendocrine cells produce bioactive peptides such as gastrin-releasing peptide (GRP) cell proliferation, and cell differentiation or maturation. Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release message molecules into the this way they bring about an integration between the nervous system and the endocrine system, a process known as neuroendocrine example of a neuroendocrine cell is a cell of. toxylin-eosin [H-E] stain) shows NECH (arrows) of a peripheral airway. The neuroendocrine cells are the small, pale staining cells under the surface epithelium. (b) Low-power photomicrograph (original magnification, ×40; H-E stain) shows a pulmonary neuroendocrine cell aggregate that measures less than 5 mm, invades the basement membrane.

  Similarly, in the literature, thymic carcinomas and high-grade pulmonary neuroendocrine neoplasms tended to have a high rate of cellular proliferation, whereas thymomas and bronchopulmonary Cited by: Neuroendocrine cells occur normally in the bronchial and bronchiolar epithelium and may be solitary or may occur in clusters. Although neuroendocrine cell proliferations may be found in association with chronic lung disease, a broad range of neuroendocrine proliferations and neoplasms may occur and exhibit variable biologic by: of neuroendocrine cells (NECs) within distal air-ways best demonstrated by bombesin and serotonin immunohistochemistry. 2 There are no formal criteria for defi ning NEC excess in the lung, but it has been Background: The diagnostic gold standard for neuroendocrine cell hyperplasia of infancy (NEHI)File Size: 2MB.   Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) refers to proliferation of pulmonary neuroendocrine cells within the walls of airways. It forms nodular or papillary cellular aggregates that may protrude into the bronchial lumen causing mucus plugging, airway obstruction, air-trapping, and bronchiectasis.